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🌱 來自: burkitt lymphoma

Definition and Pathogenesis of burkitt lymphoma

高度侵襲性B細胞NHL的特徵是什麼？

• ✋: 高度侵略性B細胞NHL，其特徵是Myc易位[t(8;14)(q24;q32)佔85％或變異體]
• 👉🏻: Highly aggressive B-cell NHL characterized by Myc translocation [t(8;14)(q24;q32) in 85% or variants]
• 🔑:B-cell NHL,Myc translocation,aggressive,variants

起源細胞是什麼？

• ✋: 起源細胞=生殖中心或生殖後中心B細胞
• 👉🏻: Cell of origin = germinal center or postgerminal center B cell
• 🔑:cell of origin,germinal center,postgerminal center,B cell

生殖中心B細胞進行Ig類切換或體細胞超突變時會引入哪種變化？

• ✋: 生殖中心B細胞在進行Ig類切換或體細胞超突變時會引入DNA斷裂
• 👉🏻: DNA breaks are introduced in germinal center B cells undergoing Ig class-switching or somatic hypermutation
• 🔑:DNA breaks,germinal center B cells,Ig class-switching,somatic hypermutation

DNA修復的錯誤會導致什麼後果？

• ✋: DNA修復的錯誤會導致易位，這種易位會將Myc的表達調控，使其受到Ig基因增強子的控制
• 👉🏻: Mistakes in DNA repair result in translocations that deregulate Myc expression by placing it under control of Ig gene enhancers
• 🔑:DNA repair,Myc expression,translocations,Ig gene enhancers

全基因組定序研究識別出了哪些常見的體細胞突變？

• ✋: 全基因組定序研究識別出了TCF3（E2A）、ID3和CCND3（cyclinD3）的常見體細胞突變（Nature 2012;490:116）
• 👉🏻: Whole genome sequencing studies identified recurrent somatic Mts in TCF3 (E2A), ID3, & CCND3 (cyclinD3) (Nature 2012;490:116)
• 🔑:whole genome sequencing,somatic mutations,TCF3 (E2A),ID3 & CCND3 (cyclinD3)