NOTE
🌱 created from: immune_complex_(ic)–associated_small-vessel_vasculitis
iga_vasculitis
- IgA-mediated small-vessel vasculitis w/ predilection for skin, GI tract, and kidneys
- Epidemiology: incidence 140/million/y; ♂ >♀, children >adults, winter >summer
- May develop ~10 d after onset of upper resp infx or after drug exposure
- Clinical manifestations
- Palpable purpura on extensor surfaces (lower extremity first) & buttocks
- Polyarthralgias (nondeforming) esp. involving hips, knees, & ankles
- Colicky abdominal pain ± GIB or intussusception Nephritis ranging from microscopic hematuria & proteinuria to ESRD
- Dx studies: skin bx w/ immunofluorescence → leukocytoclastic vasculitis w/ IgA and C3 deposition in vessel wall; renal bx → mesangial IgA deposition
- Treatment: often self-limiting over 4 wk; steroids ± DMARDs for renal or severe disease