NOTE

iga_vasculitis

  • IgA-mediated small-vessel vasculitis w/ predilection for skin, GI tract, and kidneys
  • Epidemiology: incidence 140/million/y; ♂ >♀, children >adults, winter >summer
  • May develop ~10 d after onset of upper resp infx or after drug exposure
  • Clinical manifestations
    • Palpable purpura on extensor surfaces (lower extremity first) & buttocks
    • Polyarthralgias (nondeforming) esp. involving hips, knees, & ankles
  • Colicky abdominal pain ± GIB or intussusception Nephritis ranging from microscopic hematuria & proteinuria to ESRD
  • Dx studies: skin bx w/ immunofluorescence → leukocytoclastic vasculitis w/ IgA and C3 deposition in vessel wall; renal bx → mesangial IgA deposition
  • Treatment: often self-limiting over 4 wk; steroids ± DMARDs for renal or severe disease