Info

🌱 來自: systemic lupus erythematosus

Drug-induced lupus

(DLE) (Drug Saf 2017;16:1255; Autoimmun Rev 2018;17:912)

• Many drugs: procainamide, hydralazine, penicillamine, minocycline, INH, methyldopa, quinidine, chlorpromazine, diltiazem, anti-TNF (esp. infliximab), interferons
• Abrupt onset; generally mild disease with arthritis, serositis, skin disease; renal dx, malar and discoid rash rare; prevalence ♀:♂ = 1:1
• ⊕ Anti-histone (95%) (may be ⊖ in anti-TNF); ⊖ anti-ds-DNA (often ⊕ in anti-TNF cases, even w/o manifestations of DLE) & ⊖ anti-Sm; normal complement levels
• Usually reversible w/in 4-6 wk after stopping medication