Hemolytic-uremic syndrome
Pathophys
- (1) Shiga toxin damages renal endothelial cells → intrarenal thrombi; or
- (2) complement dysregulation (hereditary or acquired), so-called “atypical HUS”
- atypical hemolytic uremic syndrome (aHUS)
- 沒有明顯 Shiga toxin 的 → HUS
Clinical
- triad =
- thrombocytopenia +
- renal failure (bloody diarrhea if Shiga)
- MAHA +
Rx
- supportive care;
- eculizumab (J Nephrol 2017;30:127); plasma exchange if CNS sx