Info
Chronic GVHD
Chronic GVHD
(developing or persisting >3 mo posttransplant; NEJM 2017;377:2565)
Clinical
- malar rash,
- sicca syndrome,
- arthritis,
- obliterative bronchiolitis,
- bile duct degeneration,
- cholestasis,
- and many others. More common w/ PBSC than BM.
Rx
- immunosuppression
- rituximab
- photopheresis
- ibrutinib (Blood 2017;130:21),
- ruxolitinib (NEJM 2021; 385:228),
- belumosudil (Blood 2021;138:2278)
- treatment of chronic graft-versus-host disease