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🌱來自: urothelial carcinoma

Cancers of the renal pelvis and ureter

Upper tract dz can also be multifocal (drop met), Histology: Urothelial CA (>90%) > SCC > adenoCA. Smoking & occupational exposure risks. Can be seen in Lynch syn Dx w/ direct ureteroscopy & bx (brushings + urine cytology if no obvious 1°) Tx of localized dz is nephroureterectomy w/ bladder cuff excision ± regional LND ± systemic chemo for high-grade/higher T stage Neoadjuvant gemcitabine + cisplatin achieved 2-y OS 89% in phase II trial (J Urol 2019;201(Suppl 4):e999) Adjuvant gemcitabine + platinum ↑ DFS in locally advanced dz (Lancet 2020;395:1268). Any nodal involvement or distant metastasis −> stage IV dz. Tx of metastatic dz is same as metastatic bladder

Siblings

• Epidemiology-of-urothelial carcinoma
• Etiology and clinical manifestations-of-urothelial carcinoma
• Pathologic Subtypes-of-urothelial carcinoma
• Workup-of-urothelial carcinoma
• Staging and prognosis-of-urothelial carcinoma
• Management of Nonmuscle invasive UC
• Management of Muscle invasive UC
• Management Metastatic UC
• Cancers of the renal pelvis and ureter
• Molecular biology and targeted therapy-of-urothelial carcinoma