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🌱 來自: Important Antibacterial Drug Interactions

Macrolides of Important Antibacterial Drug Interactions

• Substrates of CYP3A4 (e.g., warfarin, ritonavir, cyclosporine, diazepam, verapamil, amiodarone)
  • Avoid concomitant administration if possible.
• QTc-prolonging agents (e.g., fluoroquinolones, sotalol)
  • Increased risk of cardiotoxicity and arrhythmias. Monitor QTc.
• Protease inhibitors (e.g., ritonavir)
  • Can result in increased levels of both macrolides and protease inhibitors. Avoid concomitant use if possible.
• Cimetidine
  • Cimetidine can increase levels of macrolides.