see HCV

Recommended First-Line Oral Direct-Acting Antiviral (DAA) Regimens

Sofosbuvir & velpatasvir

• Genotypes 1-6, 12 weeks Rx

Glecaprevir & pibrentasvir

• Gentotypes 1-6; 8 weeks Rx

Simplified treatment

• adults w/ HCV w/o cirrhosis or w/ compensated cirrhosis & no prior HCV treatment;

• cannot have HIV, HBsAg ⊕, pregnancy, HCC, ESRD, or liver transplant;

• if decompensated or previously treated, refer to GI for assistance.

• Based on Hepatology 2020;71:686. Antiviral classes:

  • RNA polymerase inhibitor (“…buvir”);
  • NS5a inhibitor (“…asvir”);
  • NS3/4A protease inhibitor (“…previr”).