Medullary thyroid cancer
- Neuroendocrine tumor of C cells,
- peak incidence 40 to 60 y, a/w MEN2A and MEN2B
- Most commonly solitary nodule; calcitonin production (presents with diarrhea, flushing) and level used to trend dz progression, dx w/ FNA (Se 50–80%); mortality 25–50% at 5 y
- Surgery first-line treatment
MEN1 gene
- Chromosome 11q13
- 10 exons, 610-amino acid protein (menin)
-
1300 mutations