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🌱 來自: Clinical Pathway-of-breast cancer

Overview of side effects of chemotherapy for early-stage breast cancer

Taxanes

• grade 2 to 4 neuropathy occurs in 15 to 20 percent, and grade 3 or 4 neuropathy in approximately 5 percent
  • Symptoms usually improve slowly after discontinuation of treatment (over weeks to months);
• pneumonitis in approximately 5 percent
• Hepatotoxicity: one-third of patients
• Dose-related myalgias and arthralgia

Anthracyclines

• cardiotoxicity
• Malaise
• Alopecia
• Amenorrhea
• Hematologic & oncologic: Leukopenia (≤75%; nadir: 10 to 14 days; recovery: by day 21), neutropenia (≤75%; nadir: 10 to 14 days; recovery: by day 21), anemia, thrombocytopenia

Cyclophosphamide

• the most common toxicities are nausea, cytopenia, ovarian insufficiency, and fatigue. Late toxicities can include a small risk of secondary hematologic malignancies.