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Screening of hyperaldosteronism

  • ↓↓ renin,
  • aldo >15–20 ng/dL,
  • plasma aldo:renin ratio (>20 if 1°);
  • obtain 8 a.m. paired values (off spirono & eplerenone for 6 wk);
  • cut-offs arbitrary; Se var., Sp >70%