Info
diagnostic and staging evaluation of overview of lymphoma and CLL
Physical exam:
- lymph nodes,
- liver/spleen size,
- Waldeyer’s ring,
- testes (~1% of NHL),
- skin
Pathology:
- excisional lymph node bx (not FNA b/c need surrounding architecture) with immunophenotyping and cytogenetics (Reed-Sternberg (RS) cells in HL)
- BM bx if cytopenias
- CLL by peripheral flow in patients w/ peripheral disease
- LP if CNS involvement clinically suspected
Lab tests
- CBC, BUN/Cr, LFTs, ESR, LDH, UA, Ca, alb;
- ✓ HBV & HCV
- (and must ✓ HBsAg & anti-HBc if planning rituximab Rx due to risk of HBV reactivation);
- HIV
Imaging
- PET-CT to assess disease burden and guide biopsy/therapy,
- especially in HL, DLBCL.
- Head CT/MRI only if neurologic symptoms.