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🌱 來自：statistics

medical_statistics

1 Uses and Abuses of Medical Statistics 1.1 Introduction 1.2 Why Use Statistics? 1.3 Statistics is About Common Sense and Good Design 1.4 How a Statistician Can Help 2 Displaying and Summarising Data 2.1 Types of Data 2.2 Summarising Categorical Data 2.3 Displaying Categorical Data 2.4 Summarising Continuous Data 2.5 Displaying Continuous Data 2.6 Within‐Subject Variability 2.7 Presentation 2.8 Points When Reading the Literature 2.9 Technical Details 2.10 Exercises 3.1 Summarising Binary and Categorical Data 3.2 Points When Reading the Literature 3.3 Exercises 4 Probability and Distributions 4.1 Types of Probability 4.2 The Binomial Distribution 4.3 The Poisson Distribution 4.4 Probability for Continuous Outcomes 4.5 The Normal Distribution 4.6 Reference Ranges 4.7 Other Distributions 4.8 Points When Reading the Literature 4.9 Technical Section 4.10 Exercises 5 Populations, Samples, Standard Errors and Confidence Intervals 5.1 Populations 5.2 Samples 5.3 The Standard Error 5.4 The Central Limit Theorem 5.5 Standard Errors for Proportions and Rates 5.6 Standard Error of Differences 5.7 Confidence Intervals for an Estimate 5.8 Confidence Intervals for Differences 5.9 Points When Reading the Literature 5.10 Technical Details 5.11 Exercises 6 Hypothesis Testing, P‐values and Statistical Inference 6.1 Introduction 6.2 The Null Hypothesis 6.3 The Main Steps in Hypothesis Testing 6.4 Using Your P‐value to Make a Decision About Whether to Reject, or Not Reject, Your Null Hypothesis 6.5 Statistical Power 6.6 One‐sided and Two‐sided Tests 6.7 Confidence Intervals (CIs) 6.8 Large Sample Tests for Two Independent Means or Proportions 6.9 Issues with P‐values 6.10 Points When Reading the Literature 6.11 Exercises 7 Comparing Two or More Groups with Continuous Data 7.1 Introduction 7.2 Comparison of Two Groups of Paired Observations - Continuous Outcomes 7.3 Comparison of Two Independent Groups - Continuous Outcomes 7.4 Comparing More than Two Groups 7.5 Non‐Normal Distributions 7.6 Degrees of Freedom 7.7 Points When Reading the Literature 7.8 Technical Details 7.9 Exercises 8 Comparing Groups of Binary and Categorical Data 8.1 Introduction 8.2 Comparison of Two Independent Groups - Binary Outcomes 8.3 Comparing Risks 8.4 Comparison of Two Groups of Paired Observations - Categorical Outcomes 8.5 Degrees of Freedom 8.6 Points When Reading the Literature 8.7 Technical Details 8.8 Exercises 9 Correlation and Linear Regression 9.1 Introduction 9.2 Correlation 9.3 Linear Regression 9.4 Comparison of Assumptions Between Correlation and Regression 9.5 Multiple Regression 9.6 Correlation is not Causation 9.7 Points When Reading the Literature 9.8 Technical Details 9.9 Exercises 10 Logistic Regression 10.1 Introduction 10.2 Binary Outcome Variable 10.3 The Multiple Logistic Regression Equation 10.4 Conditional Logistic Regression 10.5 Reporting the Results of a Logistic Regression 10.6 Additional Points When Reading the Literature When Logistic Regression Has Been Used 10.7 Technical Details 10.8 The Wald Test 10.9 Evaluating the Model and its Fit: The Hosmer-Lemeshow Test 10.10 Assessing Predictive Efficiency (1): 2 × 2 Classification Table 10.11 Assessing Predictive Efficiency (2): The ROC Curve 10.12 Investigating Linearity 10.13 Exercises 11 Survival Analysis 11.1 Time to Event Data 11.2 Kaplan-Meier Survival Curve 11.3 The Logrank Test 11.4 The Hazard Ratio 11.5 Modelling Time to Event Data 11.6 Points When Reading Literature 11.7 Exercises 12 Reliability and Method Comparison Studies 12.1 Introduction 12.2 Repeatability 12.3 Agreement 12.4 Validity 12.5 Method Comparison Studies 12.6 Points When Reading the Literature 12.7 Technical Details 12.8 Exercises 13 Evaluation of Diagnostic Tests 13.1 Introduction 13.2 Diagnostic Tests 13.3 Prevalence, Overall Accuracy, Sensitivity, and Specificity 13.4 Positive and Negative Predictive Values 13.5 The Effect of Prevalence 13.6 Confidence Intervals 13.7 Functions of a Screening and Diagnostic Test 13.8 Likelihood Ratio, Pre‐test Odds and Post‐test Odds 13.9 Receiver Operating Characteristic (ROC) Curve 13.10 Points When Reading the Literature About a Diagnostic Test 13.11 Exercises 14 Observational Studies 14.1 Introduction 14.2 Risk and Rates 14.3 Taking a Random Sample 14.4 Questionnaire and Form Design 14.5 Cross‐sectional Surveys 14.6 Non‐randomised Studies 14.7 Cohort Studies 14.8 Case-Control Studies 14.9 Association and Causality 14.10 Modern Causality Methods and Big Data 14.11 Points When Reading the Literature 14.12 Technical Details 14.13 Exercises 15 The Randomised Controlled Trial 15.1 Introduction 15.2 The Protocol 15.3 Why Randomise? 15.4 Methods of Randomisation 15.5 Design Features 15.6 Design Options 15.7 Meta‐analysis 15.8 Checklists for Design, Analysis and Reporting 15.9 CONSORT 15.10 Points When Reading the Literature About a Trial 15.11 Exercises 16 Sample Size Issues 16.1 Introduction 16.2 Study Size 16.3 Continuous Data 16.4 Binary Data 16.5 Prevalence 16.6 Subject Withdrawals 16.7 Other Aspects of Sample Size Calculations 16.8 Points When Reading the Literature 16.9 Technical Details 16.10 Exercises 17 Other Statistical Methods 17.1 Analysing Serial or Longitudinal Data 17.2 Poisson Regression 17.3 Missing Data 17.4 Bootstrap Methods 17.5 Points When Reading the Literature 17.6 Exercises 18 Meta‐analysis 18.1 Introduction 18.2 What is a Meta‐analysis? 18.3 Meta‐analysis Methods 18.4 Example: Mobile Phone Based Intervention for Smoking Cessation 18.5 Discussion 18.6 Technical Details 18.7 Exercises 19 Common Mistakes and Pitfalls 19.1 Introduction 19.2 Misleading Graphs and Tables 19.3 Plotting Change Against Initial Value 19.4 Within Group Versus Between Group Analyses 19.5 Analysing Paired Data Ignoring the Matching 19.6 Unit of Analysis 19.7 Testing for Baseline Imbalances in an RCT 19.8 Repeated Measures 19.9 Clinical and Statistical Significance 19.10 Post Hoc Power Calculations 19.11 Predicting or Extrapolating Beyond the Observed Range of Data 19.12 Exploratory Data Analysis 19.13 Misuse of P‐values 19.14 Points When Reading the Literature