Info
🌱 來自: follicular lymphoma
Biology and Pathology of follicular lymphoma
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Composed primarily of small, cleaved lymphocytes that grow in a follicular pattern resembling that of nl 2° lymphoid tissue
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Variable numbers of larger centroblasts, w/ ↑ number indicating higher grade
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Grade I, II, & IIIA share the tx paradigm outlined below. Grade IIIB is → treated as DLBCL
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Immunophenotypically, FL cells classically express the B-cell Ags CD19 & CD20, the follicular center Ags CD10 & BCL-6, & the antiapoptotic protein BCL-2. Does not express T-cell Ags, including CD3 or CD5 (latter is → typically expressed in CLL/SLL or MCL)
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Overexpression of BCL-2,
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As w/ other lymphomas, incisional or excisional bx is → preferred for initial dx
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The term follicular center cell lymphoma is → nonspecific & may refer to FL or DLBCL
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Testicular FL, duodenal-type FL, pediatric FL, & 1° cutaneous follicle center lymphoma are rare, distinct dzs & are managed differently than classic FL