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double_hit_and_double_expressors_in_lymphoma

Riedell PA, Smith SM. Double hit and double expressors in lymphoma: Definition and treatment. Cancer. 124(24):4622-4632. doi:10.1002/cncr.31646

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Treatment for hight grade B-cell lymmphoma

  • ROBUST : A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma
  • Phoenix: Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma: 看起來是 OS 好像沒什麼差😂
  • POLARIX: 看起來是 OS 好像沒什麼差😂
  • Smart Stop

  • L-MIND: Tafasitamab plus lenalidomide in relapsed or refractory diffuse large B-cell lymphoma (L-MIND): a multicentre, prospective, single-arm, phase 2 study
    • single-arm, objective response: 34 (43%; 32–54) had a complete response and 14 (18%; 10–28) had a partial response