Info
Antidiuretic hormone
- primary hormone that regulates sodium concentration
stimuli:
- hyperosmolality (290–295 mOsm),
- ↓↓ effective arterial volume,
- angiotensin II
action:
- insertion of aquaporin-2 channels in principal cells →
- passive water reabsorption
urine osmolality
- is an indirect functional assay of the ADH-renal axis
Uosm range
- 50 mOsm/L (no ADH) to 1200 mOsm/L (maximal ADH)
- The normal range for urine specific gravity is 1.005 to 1.030.
- A specific gravity of 1.010 usually represents a urine osmolality of 300 to 350 mosm/kg