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Abiraterone

  • Given w/ steroid. Consider in high-risk dz (2 of: i. Gleason score ≥8, ii. at ↣ least 3 bone lesions, iii. measurable visceral dz). Prolongs OS vs. ADT alone in Phase III RCT (NEJM 2017;377(4):338; NEJM 2017;377(4):352)