neutropenia

(<1000/µL)

Congenital

Myelokathexis, Shwachman-Diamond-Oski, Chédiak-Higashi, retic dysgen., WHIM syndrome, cyclic neutropenia, monoMAC syndrome (↓ monos, NKs)

Infection

• Viral (CMV, EBV, HIV);
• bacterial (Brucella, Rickettsia, TB); malaria

Nutritional

Vitamin B12 or copper deficiency

Drugs and toxins

• Chemotherapeutics qv Febrile Neutropenia
• clozapine
• methimazole
• TMP-SMX
• NSAIDs,
• sulfasalazine,
• phenytoin (Am J Hem 2009;84:428),
• alcohol

Neoplasm

• MDS
• leukemia (AML, ALL, hairy cell, LGL, others)