Info

🌱 來自: acute leukemia

clinical manifestations of acute leukemia

• Cytopenias → fatigue (anemia), infection (neutropenia), bleeding(thrombocytopenia)

Leukostasis (more in AML):

• blast >50k,
• ↓ SaO2,
• HA,
• blurry vision,
• confusion,
• TIA/CVA

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•  Tumor lysis syndrome (TLS) from rapid turnover of cells
•  Disseminated intravascular coagulation (DIC; especially with APL)
• leukemic infiltration of skin
• gingiva (esp. with monocytic subtypes);
• chloroma (myeloid sarcoma):
• extramedullary tumor of leukemic cells
• anterior mediastinal mass and SVC syndrome (T-ALL/LBL)
• hepatosplenomegaly (ALL and monocytic leukemias);
• CNS (~10% of ALL; also in monocytic >myeloid leukemias) : cranial neuropathies, headache