Definition-acute kidney injury (AKI)

(KDIGO 2012;2:1)

Stages in ICU correspond to ↑ hospital mortality and LOS (Crit Care Med 2009;37:2552)

Diagnostic criteria

• Increase in serum creatinine of ≥0.3 mg/dL within 48 hours or ≥50% within 7 days
• Urine output of <0.5 mL/kg/hour for >6 hours

Stage 1:

• Cr ≥0.3 mg/dL in 2d
• ↑ Cr ≥50%~100%
• UOP <0.5 mL/kg/h for ≥6h

Stage 2:

• ↑ Cr 2–3x baseline in 7d
• UOP <0.5 mL/kg/h ≥12h

Stage 3:

• ↑ 3x baseline in 7d,
• UOP <0.3 mL/kg/h for ≥24h,
• anuria ≥12h
• Cr >4
• Initiation of kidney replacement therapy

others

Cannot estimate GFR using Cr in setting of AKI or ∆’ing Cr (requires steady state) In patients <18 years, stage 3 AKI is also defined by KDIGO as a decrease in estimated glomerular filtration rate (eGFR) to <35 mL/min/1.73 m2.

Explain by ChatGPT

Acute kidney injury (AKI) is a sudden decrease in kidney function.

There are three stages of AKI:

Stage 1: A creatinine level increase of 0.3 mg/dL within 48 hours or an increase of 50% within 7 days.

Stage 2: A creatinine level increase of 2-3 times the baseline within 7 days.

Stage 3: A creatinine level increase of 3 times the baseline within 7 days.

窩的英文不太好

急性腎損傷 (AKI) 是腎功能突然下降。

AKI 分為三個階段：

1. 第 1 階段：肌酐水平在 48 小時內增加 0.3 mg/dL 或在 7 天內增加 50%。

2. 第 2 階段：肌酐水平在 7 天內增加到基線的 2-3 倍。

3. 第 3 階段：肌酐水平在 7 天內增加到基線的 3 倍。