IgA vasculitis

(formerly Henoch-Schönlein purpura [HSP]) (Rheumatol 2019;58:1607)

• IgA-mediated small-vessel vasculitis
  • w/ predilection偏好 for skin, GI tract, and kidneys

Epidemiology:

* incidence 140/million/y;
* 冬天的女孩
	* ♂ >♀,
	* children >adults,
	* winter >summer
* May develop ~10 d after onset of upper resp infx or after drug exposure

• Clinical manifestations of IgA vasculitis
• Dx studies:
  • skin bx w/ immunofluorescence → leukocytoclastic vasculitis w/ IgA and C3 deposition in vessel wall;
  • renal bx → mesangial IgA deposition

Treatment:

* often self-limiting over 4 wk;
* steroids ± DMARDs for renal or severe disease

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[Henoch-Schonlein purpura | Circulatory System and Disease | NCLEX-RN | Khan Academy - YouTube](https://www.youtube.com/watch?v=pZcNmGtp5SA&ab channel=khanacademymedicine)