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🌱來自: castleman_disease
Epidemiology
- The incidence of UCD is 16 per million patient-years and affects all age groups.
- The incidence of HHV-8 associated CD varies widely, but it is more common in HIV-positive men.
- The incidence of iMCD is 5 per million patient-years.
- The hyaline-vascular variant is more common than the plasma-cell type, comprising 91% of the total cases.
- Its predominance in any specific sex or race is not noted.
- Castleman disease usually develops in most patients before reaching 30, although the age range is broad.
Siblings
- A 41-Year-Old Man with Dyspnea, Fever, and Lymphadenopathy
- CT of the Chest, Abdomen, and Pelvis
- Histopathological Presentation
- Bone marrow examination
- Diagnosis
- Definition
- Classification
- Pathogenesis
- Pahtogenesis (continued)
- Histopathological of Castleman Disease
- Histopathological of Castleman Disease (continued)
- Follicles With Mantle Zones With An “Onion Skin” Pattern
- Hyaline vascular Castleman disease
- Grading of pathologic features seen in iMCD
- Algorithmic approach for assessment of lymph node with features of CD
- Diagnostic criteria for iMCD
- Significant clinical, histologic, and immunologic overlap
- Conditions Characterized by Inflammation and Differential Diagnosis for iMCD
- Diagnostic criteria for iMCD-TAFRO
- Severity scoring of iMCD
- The management of UCD
- Management of iMCD
- IL-6 pathway
- IL-6 Inhibitors
- Siltuximab for multicentric Castleman’s disease
- Definitions of Treatment Response
- Which type of biopsy would you use in order to prevent the delay of a Castleman disease diagnosis?
- According to guidelines, which type of therapy is most optimal for your patient with idiopathic multicentric Castleman disease?
- What is required for the diagnosis of iMCD?
- Which of the following is true regarding the diagnosis of iMCD?
- Take home message
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