Definition-glomerulonephritis

Lancet 2016;387:2036; JASN 2016;27:1278)

參考 ➡️ Mayo clinic/renal pathology society consensus report on pathologic classification, diagnosis, and reporting of GN 參考 ➡️ Primary glomerulonephritides

• ↑ glomerular inflammation → endothelial & podocyte injury

• Histology: proliferative (↑ cells), sclerosing (scar), necrotizing (areas cell death). Focal (<50% of glomeruli) to diffuse to crescentic. Segmental (<50% tuft) to global (100%).

• Clinically: hematuria w/ dysmorphic red blood cell or RBC casts, ± subnephrotic proteinuria often w/ AKI, HTN, edema

• Progression: acute ≈ days; rapid progressive glomerulonephritis (RPGN) ~6 wk; chronic ≈ mos; can be asx