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🌱 來自: gastric cancer

Genetics-of-gastric cancer

Familial cases account for up to 5-10% of all gastric CA Lynch: Germline muts of MMR genes (MSH2, MLH1, MLH6, PMS2, EPCAM) Diffuse hereditary gastric CA: Germline E-cadherin (CDH1) mut, AD, 60-80% penetrance, consider ppx gastrectomy (NEJM 2001;344:1904) Others: FAP, Li-Fraumeni, juvenile polyposis, Peutz-Jeghers