Treatment-chronic pancreatitis

(JAMA 2019;322:2422; Lancet 2020;396:499)

• Pancreatic enzyme replacement (may ↓ pain by reducing CCK). Rx routine vitamin D & Ca.

• Pain control: smoking & EtOH cessation, analgesics (start with non-opioids; eg, pregabalin), endoscopy (stone removal or stenting strictures), celiac nerve plexus block, surgery