Info

🌱 來自: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia

differential diagnosis of pancytopenia

Pancytopenia with Hypocellular Bone Marrow

• Acquired aplastic anemia
• Constitutional aplastic anemia (Fanconi anemia, dyskeratosis congenita, and others)
• Hypocellular myelodysplastic syndrome
• Rare aleukemic leukemia
• Some acute lymphoid leukemia
• Rare lymphomas of bone marrow
• Copper deficiency

Pancytopenia with Cellular Bone Marrow

Primary bone marrow diseases

•  Myelodysplastic syndromes
•  Paroxysmal nocturnal hemoglobinuria (PNH)
•  Myelofibrosis
•  Aleukemic leukemia
•  Myelophthisis

Bone marrow lymphoma

Hairy cell leukemia

Secondary to systemic diseases

•  Systemic lupus erythematosus

•  Hypersplenism

•  B12, folate deficiency

•  Copper deficiency

•  Alcohol

•  HIV infection

•  Brucellosis

•  Sarcoidosis

•  Tuberculosis

•  Leishmaniasis

•  Sepsis

Hypocellular Bone Marrow ± Pancytopenia

• Q fever
• Legionnaires’ disease
• Anorexia nervosa, starvation
• Mycobacterium