👉 COPD Exacerbation Treatment

Corticosteroids of COPDAE

• Prednisone 40 mg/d × 5d (JAMA 2013;309:2223); some Pts will benefit from higher dose/longer course if severe

• Methylprednisolone 125 mg IV q6h × 72 h for more severe exacerbations

• ↓ treatment failure, ↓ hosp. stay

• ↑ FEV1 but no mortality benefit,

• ↑ complications (Cochrane 2009:CD001288)

• OutPt Rx after ED visit ↓ relapse (NEJM 2003;348:2618)