Info

🌱 來自: small lymphocytic lymphoma

clinical manifestations of small lymphocytic lymphoma

- Often asx & identified by lymphocytosis on CBC; 10–20% p/w “B symptoms”

- Lymphadenopathy (80%) and hepatosplenomegaly (50%)

- Autoimmune hemolytic anemia (AIHA) (~10%) or thrombocytopenia (ITP) (~1–2%)

• Hypogammaglobulinemia ± neutropenia → ↑ susceptibility to infections

• Bone marrow failure in ~13%; monoclonal gammopathy in ~5%

• Aggressive Richter’s transformation in ~5% into high-grade lymphoma (poor prognosis)