Info
🌱 來自: Huppert’s Notes
Autoimmune Etiologies of Liver Disease🚧 施工中
Autoimmune Etiologies of Liver Disease
Autoimmune hepatitis
• Epidemiology: F:M = 4:1, associated with other autoimmune conditions
• Clinical features: Variable presentation from asymptomatic to acute liver failure
• Diagnosis:
- Type 1: +ANA, +anti-smooth muscle (65%), +anti-actin, +anti-mitochondrial (with PBC overlap), anti-SLA/LP (10–30%), anti-dsDNA (25–35%), +pANCA
- Type 2: +ALKM-1, +/−ALC-1
- Liver biopsy
• Treatment: Steroids +/−azathioprine. Indications: AST>10× ULN, AST>2× ULN and IgG level >2× ULN, bridging fibrosis, cirrhosis. Advanced disease may require liver transplantation.