Info
Definition epidemiology pathology of hypertrophic cardiomyopathy
- LV (usually ≥15 mm) and/or RV hypertrophy disproportionate to hemodynamic load
- Due to gene mutations affecting proteins of or related to sarcomere; prev.: ~1/200-500
- Myocardial fiber disarray with hypertrophy, which creates arrhythmogenic substrate
- Many morphologic hypertrophy variants: asymmetric septal; concentric; midcavity; apical
- Ddx: LVH 2° to HTN, AS, elite at ↣ hletes (wall usually <13 mm & symmetric and nl/↑ rates of tissue Doppler diastolic relaxation; Circ 2011;123:2723), Fabry dis. (↑ Cr, skin findings)