Thrombotic microangiopathies

(TMA; NEJM 2014;371:654; Lancet 2017;390:681)

Endothelial injury → plt aggreg. & microvasc. thrombosis → ↓ plt & RBC hemolysis (MAHA)

Diagnosis of Thrombotic microangiopathies

thrombotic thrombocytopenic purpura

hemolytic-uremic syndrome (HUS)

drug-induced TMA

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Disseminated intravascular coagulation (DIC)