Dronedarone
n/a 400 mg bid decrease side effects & effic. vs. Amiodarone
Dronedarone, which lacks iodine moieties of amiodarone, slows the resting rate in AF by an average of 12 bpm and also improves exercise heart rate control303; however, it should not be used for rate control in permanent AF, as it was found to increase rates of HF, stroke, cardiovascular death, and unplanned hospitalization.282 Furthermore, dronedarone should not be used for ventricular rate control in patients with HF and LV systolic dysfunction because it increases the likelihood of the combined endpoint of stroke, MI, systemic embolism, or cardiovascular death.