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Pathophysiology of acute respiratory distress syndrome
(Lancet 2016;388:2416)
- ↑ intrapulmonary shunt → hypoxemia (∴ Rx w/ PEEP to prevent derecruitment)
- ↑ increased dead space fraction (see Appendix), predicts ↑ mort (NEJM 2002;346:1281)
- ↓ compliance: VT/(Pplat – PEEP) <50 mL/cm H2O
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