NOTE

🌱 created from: treatment-of-myelofibrosis

fedratinib

  • BRD4 had better NF-kappaB response than BRD2 in the first place
  • Montior for thiamine deficiency, get baseline when starting treatment
  • If Wernicke Encephalopathy, hold off treatment

Regular dose 400 mg/day or 300 mg/day

  • Common side effects include:
    • Diarrhea in the first month

as 2nd line

FREEDOM2