Info

METex14

  • Mt: 3-4% of ADCL, Mts lead to exon 14 skipping (ubiquitin-binding site) & persistent activation;
  • a/w sarcomatoid carcinoma. Can be 2° to EGFR Mt. Sn to MET inhibitors (Nat Rev Clin Oncol 2020;17:569)