Info
classification of acute myelogenous leukemia (AML)
(WHO; Blood 2016;127:2391)
- blasts,
- ⊕ granules,
- ± Auer rods(eosinophilic needle-like inclusions)
Immunophenotype:
- precursor: CD34, CD45, HLA-DR;
- myeloid: CD13, CD33, CD117;
- monocyte: CD11b, CD64, CD14, CD15
Histochem
- myeloperoxidase (myeloid)
- non-specific esterase
- lysozyme (monocytic)
Prognosis
- age
- prior antecedent MPN/MDS and genetics
- (cytogenetics + molecular mutation status)
also look at: FAB classification system