Risk factors-acute aortic syndromes

(Lancet 2015;385:800)

• Classic (in older Pts):
  • HTN (h/o HTN in >70% of dissections);
  • age (60s–70s), sex (~65% ♂);
  • smoking
  • ↑ lipids.
  • Acute ↑ BP: cocaine, Valsalva (eg, weightlifting).
• Genetic:
  • CTD (Marfan, Loeys-Dietz, Ehlers-Danlos type IV);
  • congenital anomaly (bicuspid AoV, coarct [eg, Tuner’s syndrome], PCKD);
  • FHx (AoD or aneurysm in 1st degree relative)
• Acquired:
  • aortitis
    • Takayasu’s,
    • GCA,
    • Behçet’s,
    • syphilis
  • preg. (typically 3rd trim.);
  • FQ use
• Trauma:
  • blunt, decel. injury (eg, MVA);
  • IABP, cardiac/aortic surgery,
  • Impella, cardiac cath