Info

🌱 來自: non-Hodgkin lymphoma (NHL)

WHO Classification of Lymphoid Malignancies

(Blood 2016;127:2375)

Mature B cell

• Burkitt’s lymphoma
  • 8q24, c-MYC
• Diffuse large B-cell lymphoma (DLBCL)
  • BCL2, MYC, MLL2, CREBBP, etc.
• Mantle cell lymphoma
  • t(11;14) BCL1-IgH → cyclin D1
• Marginal zone lymphoma (nodal, extranodal, splenic)
  • AP12-MALT1 & BCL-10-Ig enh
• Hairy cell leukemia (⊕ TRAP)
  • BRAF V600E
• Follicular lymphoma
  • IGH-BCL2, MLL2, CREBBP
• small lymphocytic lymphoma IGHV, TP53, ATM, SF3B1, etc.

Mature T cell & NK cell

• Peripheral T-cell lymphoma
  • TET2 and DNMT3A
• Mycosis fungoides (cutaneous lymphoma)/ Sézary syndrome (+ LAN)
  • Some ALK1 ⊕
• Anaplastic large-cell lymphoma
• Angioimmunoblastic T-cell lymphoma