Info

🌱 來自: polycythemia vera (PV)

diagnostic evaluation of polycythemia vera

• Men: Hb >16.5 g/dL or Hct >49%, women: Hb >16 g/dL or Hct >48%
• ± ↑ WBC, platelets, basophils; ↑ uric acid, leukocyte alkaline phosphatase, vit B12
• Peripheral smear → no morphologic abnormalities
• ✓ Epo to rule out secondary causes of erythrocytosis; if Epo ↓, PV more likely If Epo ↑, then ✓ SaO2 or PaO2, carboxyhemoglobin, BM exam
• BM bx → hypercellularity for age, trilineage growth, pleomorphic mature megakaryocytes
• JAK2 V617F mutation in ~95% of PV;
  • other Pts typically harbor _JAK2_exon 12 mutations