Info
🌱 來自: Huppert’s Notes
Peripheral Eosinophilia and Hypereosinophilia Syndromes🚧 施工中
Peripheral Eosinophilia and Hypereosinophilia Syndromes
• Definition
- Eosinophilia: Absolute eosinophil count >500/μl (500–1500/μl more likely due to atopic disease)
- Hypereosinophilia: Severe eosinophilia >1500/μl; worry especially if >5000/μl since risk of end organ damage increases (e.g., eosinophilic dermatitis, myocarditis, hepatitis)
• Etiologies:
- Neoplasms:
• Monoclonal: Primary hypereosinophilic syndrome (can check for mutations like PDGFRB, PDGFRA, FGFR-1, AEL, and CEL, which cause a monoclonal eosinophil proliferation)
• Polyclonal: T-cell lymphoma, Hodgkin’s lymphoma, some solid organ malignancies cause reactive eosinophilia (e.g., cervical cancer, ovarian cancer, SCC, gastric and colon cancer, urothelial cancer)
- Allergies, which includes asthma and drug-induced eosinophilia (including DRESS)
- Adrenal insufficiency
- Connective tissue diseases: Eosinophilic granulomatosis with polyangiitis (eGPA) and rheumatoid arthritis
- Parasites
• Lymphatic filiariasis, toxocara, trichinosis and strongyloides can all cause an eosinophil count >5000/μl. Only multicellular parasites cause eosinophilia.
• Other infections may also cause lower degrees of eosinophilia (e.g., ABPA, cocci, HIV)
- Organ-restricted hypereosinophilic conditions (e.g., eosinophilic fasciitis, eosinophilic cellulitis, etc.) can cause peripheral eosinophilia