First-line or upfront therapy for idiopathic thrombocytopenic purpura
Steroids:
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prednisone 0.5–2 mg/kg/d PO tapered ~4 wk, or dexamethasone 40 mg PO × 4 d
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↓ Mϕ FcR & ↓ anti-plt Ab
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70–90% have initial response
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~20% sustained remission
IVIg (1 g/kg/d IV × 2–3 d)
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Consider if need rapid ↑ in plt in 24–48 hrs; lasts 2–6 wks
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Blocks Mϕ FcR, ↓ anti-plt Ab
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Interferes w/ Mϕ uptake Ab-coated plts; 80% have initial response
Anti-Rh(D) Ig:
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alternative to IVIg if RBC Rh(D) ⊕; 50–75 mcg/kg/d
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Ab-coated RBCs overwhelm Mϕ FcR
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Avoid if h/o hemolysis; not often used