Definition-Antiphospholipid syndrome

dx requires ≥1 clinical & ≥1 laboratory criteria

Clinical: thrombosis (any) or complication of pregnancy (≥3 spont. abortions before 10 wk or ≥1 fetal loss after 10 wk or premature birth before 34 wk)

Laboratory: ⊕ lupus anticoagulant (LA), or ⊕ moderate–high titer anticardiolipin (ACL), or ⊕ β2-glycoprotein-I (β2-GP-I) Ab, on ≥2 occasions, at least 12 wk apart