Info

🌱 來自: plasma cell dyscrasias

spectrum of nonmalignant to malignant clonal plasma cell disorders

1. MUGS
   • TLDR: M protein < 3g
2. Smoldering multiple myeloma
   • TLDR: No crab
3. multiple myeloma

Monoclonal Gammopathy of Uncertain Significance (MGUS)

Smoldering Multiple Myeloma

• 10-60% bone marrow plasma cells

• 3g/dL serum M protein

• 500mg/24hr urine M protien

• Need whole-body MRI or PET-CT to rule out occult bone lesions

• Risk of prog. 10%/y, depends on [M protein], subtype, FLC ratio. No defined role for Rx yet though trials ongoing (NEJM 2013;369:438; Blood 2019;134:781; JCO 2020;38:1126).

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No myeloma defining events

• monoclonal gammopathy of uncertain significance
• Smoldering multiple myeloma

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multiple myeloma

• 10% bone marrow plasma cells

• Bx-proven plasmacytoma

and +1 myeloma defining event