Clopidogrel
300–600 mg × 1 → 75 mg qd ~6 h to steady state Wait 5 d prior to surgery ASA+clopi → 20% ↓ CVD/MI/stroke vs. ASA alone. ~30% pop has ↓ fxn CYP2C19 → ↑ CV events if PCI on clopi (NEJM 2009;360:354).
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Jan 01, 20241 min read
300–600 mg × 1 → 75 mg qd ~6 h to steady state Wait 5 d prior to surgery ASA+clopi → 20% ↓ CVD/MI/stroke vs. ASA alone. ~30% pop has ↓ fxn CYP2C19 → ↑ CV events if PCI on clopi (NEJM 2009;360:354).