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definition of small lymphocytic lymphoma

(NEJM 2005;352:804; Blood 2008;111:5446)

  • Monoclonal, functionally incompetent mature B lymphocytes; CLL & SLL = same disease

    • CLL: >5000/µL malignant cells;
    • SLL: <5000/µL malignant cells
      • LAN ± splenomegaly
  • Monoclonal B lympho-CYTOSIS:

    • resembles but does not meet CLL criteria, observe