Drug-induced hemolytic anemia

• Acquired, Ab-drug mediated destruction vs. direct drug effect. Abx: ceph., sulfa drugs, rifampin, ribavirin. CV: methyldopa, procainamide, quinidine, thiazides. TCAs, phenothiazines, NSAIDs, sulfonylureas, MTX, 5-FU, rasburicase (G6PD defic.)

• Diagnosis: Coombs’ usually negative, ↑ LDH; Treatment: discontinue offending agent