anion gap

• (AG) = Na+ – (Cl– + HCO3–) = unmeasured anions – unmeasured cations If ↑ glc, use measured not corrected Na

Expected AG is [albumin] × 2.5 (ie, 10 if albumin is 4 g/dL, 7.5 if albumin is 3 g/dL) ↑ AG → ↑ unmeasured anions such as organic acids, phosphates, sulfates ↓ AG → ↓ alb or ↑ unmeasured cations (Ca, Mg, K, Li, Ig), bromide/iodine toxicity

• If ↑ AG, ✓ delta-delta