fever of unknown origin

  • (continuous or recurrent) and duration, previous medical history, present and recent drug use, family history, sexual history, country of origin, recent and remote travel, unusual environmental exposures associated with travel or hobbies, and animal contacts.

Definition & etiologies (NEJM 2022;386:463)

  • Fever (as per above def) on >1 occasion during ≥3 wk & no dx despite 1 wk of evaluation
  • More likely to be unusual manifestation of common disease than an uncommon disease
  • In Pts with HIV: >75% causes are infectious, but rarely due to HIV itself
  • Frequent reassessment needed to identify focal signs and progression of disease Etiologies of Classic FUO Workup-fever of unknown origin (Archives 2009;169:2018; AJM 2015;128:1138) Treatment-fever of unknown origin

Definition of fever of unknown origin