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Epidemiology of Localized Prostate Cancer

  • Incidence: ∼248,500, leading cause of CA in men (CA Cancer J Clin 2021;71(3):209).
  • Annual Mortality: ∼34,000, 2nd highest cause of CA death in men in the U.S. (CA Cancer J Clin 2021;71(1):7).
  • Declining mortality: 1992 was 39 & 2017 was 19/100,000
  • RFs:
    • Age (rare before 40 y),
    • Black race,
    • 1st-degree relative <65 y w/ prostate CA,
    • BRCA2,
    • ATM,
    • Lynch syn