NOTE

🌱 created from: cryoglobulinemia

clinical_manifestations_of_cryoglobulinemia

• Type I:
  • hyperviscosity (cold worsens sx) →
    • HA,
    • visual Δ,
    • livedo,
    • digital ischemia
• Type II/III:
  • vasculitis (not affected by cold) → fever,
  • derm
    • (54–80%; purpura, livedo reticularis, ulcers),
  • arthralgia
    • (44–70%; symmetric migratory, small/med joints),
  • glomerulonephritis
    • (50%; MPGN),
  • neurologic (17–60%; peripheral neuropathy
    • (polyneuropathy > mononeuritis multiplex),
  • ↓ Hgb,
  • ↓ plt,
  • ↑ B-cell lymphoma risk,
  • GI (5%; pain, HSM, ↑ LFTs).
• Meltzer’s triad:
  • purpura,
  • arthralgias,
  • weakness in 25–30%.